In this article, I bring together the archive of institutional activism of Niara Sudarkasa in the U.S. and the posthumous impact of activist and public administrator Marielle Franco. The 1970s historical sources show Sudarkasa’s institutional solidarity with students and faculty in the creation of one of the first Africana Studies departments in the U.S. Reading them, I articulate an ethos for the curation ‘715 Haven Street: Art Looks Back,’ a public digital art gallery comprised of art and history found in (...) the DAAS Papers (Department of Afroamerican and African Studies) housed in the Bentley Library’s digital and physical archives. The analysis of the primary sources is guided by an engagement with the ‘Marielle Effect,’ generating a historical parameter for Abolitionist solidarity between American, Brazilian, Latin American, African American, Diasporic, and ally scholarly communities. The discussion of these parameters is embedded in my discussion of the concept of pacification, a phenomenon of colonial and post-colonial policing that survives through the perpetuation of an extra-judicial policing impetus articulated along race, identity, legality, and sexual legitimacy of subjects. (shrink)

In this article I wish to show how care ethics puts forward a fundamental critique on the ideal of independency in human life without thereby discounting autonomy as a moral value altogether. In care ethics, a relational account of autonomy is developed instead. Because care ethics is sometimes criticized in the literature as hopelessly vague and ambiguous, I shall begin by elaborating on how care ethics and its place in ethical theory can be understood. I shall stipulate a definition of (...) care ethics as a moral perspective or orientation from which ethical theorizing can take place. This will mean that care ethics is more a stance from which we can theorize ethically, than ready-made theory in itself. In conceiving care ethics in this way, it becomes possible to make clear that, for instance, a moral concept of autonomy is not abandoned, but instead is given a particular place and interpretation. In the final part of this article I will show how ‘relational autonomy’ can be applied fruitfully in the practice of psychiatric care. (shrink)

In an age of global capitalism, pandemics, far-flung biobanks, multinational drug trials and telemedicine it is impossible for bioethicists to ignore the global dimensions of their field. However, if they are to do good work on the issues that globalisation requires of them, they need theoretical resources that are up to the task. This paper identifies four distinct understandings of ‘globalised’ in the bioethics literature: a focus on global issues; an attempt to develop a universal ethical theory that can transcend (...) cultural differences; an awareness of how bioethics itself has expanded, with new centres and journals emerging in nearly every corner of the globe; a concern to avoid cultural imperialism in encounters with other societies. Each of these approaches to globalisation has some merit, as will be shown. The difficulty with them is that the standard theoretical tools on which they rely are not designed for cross-cultural ethical reflection. As a result, they leave important considerations hidden. A set of theoretical resources is proposed to deal with the moral puzzles of globalisation. Abandoning idealised moral theory, a normative framework is developed that is sensitive enough to account for differences without losing the broader context in which ethical issues arise. An empirically nourished, self-reflexive, socially inquisitive, politically critical and inclusive ethics allows bioethicists the flexibility they need to pick up on the morally relevant particulars of this situation here without losing sight of the broader cultural contexts in which it all takes place. (shrink)

There are several recent and noteworthy studies on the testimonies and fragments of Melissos of Samos: Laks-Most, Brémond. Furthermore, one can learn a great deal about Melissos from the lectures and discussions undertaken in the framework of “Eleatica 2012”. When taken together, these studies enable us to fully appreciate Melissos’ original work in terms of its sources, its audacious arguments and its later criticisms. Melissos is here presented as a spokesman of the Eleatic school in an order that aims to (...) do justice to the ancient testimonies that relate and refute his arguments as well as to the verbatim fragments. For the sake of clarity, however, various secondary testimonies have been omitted. (shrink)

Borrett, Kelly and Kwan [ Phenomenology, dynamical neural networks and brain function, Philosophical Psychology, 13, 000-000] claim that unbiased, self-evident, direct description is possible, and may supply the data that brain theories account for. Merleau-Ponty's [ Phenomenology of perception, London: Routledge] description of Schneider's apraxia is offered as a case in point. According to the authors, Schneider's apraxia justifies brain components of predicative and pre-predicative experience. The description derives from a bias, however, that parallels modularity's morphological reduction. The presence of (...) biasing presuppositions contradicts the goal of direct description. Moreover, the authors' brain account is not necessary to explain Schneider's apraxia, and morphological reduction is not sufficient to explain emergent phenomena of motor control. (shrink)

It is not uncommon that nurses are unable to meet the normative expectations of chronically ill patients. The purpose of this article is to describe and illustrate Walker’s expressive-collaborative view of morality to interpret the normative expectations of two women with multiple sclerosis. Both women present themselves as autonomous persons who make their own choices, but who also have to rely on others for many aspects of their lives, for example, to find a new balance between work and social contacts (...) or to find work. We show that their narratives of identity, relationship and value differ from the narratives that others use to understand and identify them. Since identities, relationships and values give rise to normative expectations, in both cases there is a conflict between what the women expect of their caregivers and vice-versa. The narratives also show that two similar persons with multiple sclerosis may need very different care. This implies that nurses caring for such persons should listen carefully to their stories and reflect on their own perceptions of self. (shrink)

Cis‐regulatory elements govern gene expression programs to determine cell identity during development. Recently, the possibility that multiple enhancers are orchestrated in clusters of enhancers has been suggested. How these elements are arranged in the 3D space to control the activation of a specific promoter remains unclear. Our recent work revealed that the TGFβ pathway drives the assembly of enhancer clusters and precise gene activation during neurogenesis. We discovered that the TGFβ pathway coactivator JMJD3 was essential in maintaining these structures in (...) the 3D space. To do that, JMJD3 required an intrinsically disordered region involved in forming phase‐separated biomolecular condensates found in the enhancer clusters. Our data support the existence of a relationship between 3D‐conformation of the chromatin, biomolecular condensates, and TGFβ‐driven response during mammalian neurogenesis. In this review, we discuss how signaling (TGFβ), epigenetics (JMJD3), and biochemical properties (biomolecular condensates nucleation) are coordinated to modulate the genome structure to guarantee proper neural development. Moreover, we comment on the potential underlying mechanisms and implications of the enhancer‐mediated regulation. Finally, we point out the knowledge gaps that still need to be addressed. (shrink)

They reject the correspondence theory, insist truth is anemic, and advance an "anti-theory" of truth that is essentially a collection of platitudes: "Snow is white" is true if and only if snow is white; "Grass is green" is true if and only if grass is green. According to disquotationalists, the only profound insight about truth is that it lacks profundity. David contrasts the correspondence theory with disquotationalism and then develops the latter position in rich detail - more than has been (...) available in previous literature - to show its faults. (shrink)

A central issue confronting both philosophers and practitioners in formulating an analysis of causation is the question of what constitutes evidence for a causal association. From the 1950s onward, the biostatistician Jerome Cornfield put himself at the center of a controversial debate over whether cigarette smoking was a causative factor in the incidence of lung cancer. Despite criticisms from distinguished statisticians such as Fisher, Berkson and Neyman, Cornfield argued that a review of the scientific evidence supported the conclusion of a (...) causal association. Cornfield's odds ratio in case‐control studies — as a good estimate of relative risk — together with his argument of ''explanatory common cause'' became important tools to use in confronting the skeptics. In this paper, I revisit this important historical episode as recorded in the Journal of National Cancer Institute and the Journal of the American Statistical Association. More specifically, I examine Cornfield's necessary condition on the minimum magnitudes of relative risk in light of confounders. This episode yields important insight into the nature of causal inference by showing the sorts of evidence appealed to by practitioners in supporting claims of causal association. I discuss this event in light of the manipulationist account of causation. (shrink)

The present research is a historical perspective on luxury during 1781-1933. The major stake is represented by the response of the ecclesiastical authority to luxury, the rejection/blaming/damning of luxury; subsequently the acceptance of it. We notice here the church's incapacity to stop the 'illegitim' consumption, that kind of consumption which was beyond the possibilities of a common person, and the taxation of luxury - the one who had more than he/she needed had to donate to the Church, meaning to the (...) poor. The secular authority did the same - luxury would be progressively taxed, which led to a certain synchronization between Church and State. We also analyse the link between orthodoxy and consumption from sociological perspective. The excess is perceived as being a sin. That is why the Church undertakes the role of prescriptor/controller of consumption, be it dressing, food etc. We detect here stages in the process of modernizing of the Romanian cultural space, the social changing and stratification. Luxury was a benchmark in social comparison, a reason of frustration, of indignation, of philosophical reflection. Luxury is a key for understanding the struggle between old and new, between ethics promoted by the Church and that of liberalism, about the tension between traditional consumption (home-made, predictable, swimming with the stream) and the one generated by the circulation of goods, by the industrial revolution. (shrink)

Fifty years later it is still necessary to talk about some decisions of Second Vatican Ecumenical Council regarding the role of the layperson as the Church's mission participant and also its fundamental role concerning the dialogue between Church and the world, as discussed throughout the Council and singularly in the Pastoral Constitution Gaudium et Spes. It can be seen throughout history that the layman, somewhat, could see himself forgotten, taking part in the Church passively. This thought, however, is changing from (...) what was said at the Council as its several documents show: the layman as a transforming agent in the Church but, more essencially, out of it, it is recognized its important role as participants in the mission. So we talk about the Mission of the Church and the Council contributions to this new understanding of the laity, the role of the layperson in the Church, the importance of dialogue between the Church and the world and finally, the layman as the main agent in this dialogue. (shrink)

To study animal welfare empirically we need an objective basis for deciding when an animal is suffering. Suffering includes a wide range ofunpleasant emotional states such as fear, boredom, pain, and hunger. Suffering has evolved as a mechanism for avoiding sources ofdanger and threats to fitness. Captive animals often suffer in situations in which they are prevented from doing something that they are highly motivated to do. The an animal is prepared to pay to attain or to escape a situation (...) is an index ofhow the animal about that situation. Withholding conditions or commodities for which an animal shows (i.e., for which it continues to work despite increasing costs) is very likely to cause suffering. In designing environments for animals in zoos, farms, and laboratories, priority should be given to features for which animals show inelastic demand. The care ofanimals can thereby be based on an objective, animal-centered assessment of their needs. (shrink)

Truthmakers have come to play a central role in David Armstrong's metaphysics. They are the things that stand in the relation of truthmaking to truthbearers. This chapter focuses on the relation. More specifically, it discusses a thesis Armstrong holds about truthmaking that is of special importance to him; namely, the thesis that truthmaking is an internal relation. It explores what work this thesis is supposed to do for Armstrong, especially for this doctrine of the ontological free lunch, raising questions and (...) pointing out difficulties along the way. At the end of the chapter, it is shown that Armstrong's preferred truthbearers generate a serious difficulty for his thesis that the truthmaking relation is internal. (shrink)

This paper draws on the economics of ethical compliance model to examine the association between ethical reasoning, perceived risk of detection, perceived levels of penalties and Chinese auditors'' ethical behavior in an audit conflict situation. Using 53 Chinese auditors from Shenzen as subjects, and a survey questionnaire, this study found that there is a significant negative association between ethical reasoning and the likelihood of unethical behavior and that this negative association is weaker for auditors who perceive higher risks of detection.

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

Roderick Chisholm appears to agree with Kant on the question of the existence of synthetic a priori knowledge. But Chisholm’s conception of the a priori is a traditional Aristotelian conception and differs markedly from Kant’s. Closer scrutiny reveals that their agreement on the question of the synthetic a priori is merely verbal: what Kant meant to affirm, Chisholm denies. Curiously, it looks as if Chisholm agreed on all substantive issues with the empiricist rejection of Kant’s synthetic a priori. In the (...) end, it turns out that Chisholm disagrees with both, empiricism and Kant, over a fundamental question: whether mere understanding of the contents of our thoughts must always remain within the circle of our own ideas or can provide us with genuine knowledge of matters of fact. (shrink)

This book covers the theory of our moral behavior that seems to meander throughout the history of ideas and that led eventually to scientific explanation of human moral behavior with various interpretations of the natural moral law.

I this paper I give minimal axioms for the ontology of time, especially A-theories and B-theories and I derive philosophically interesting lemmas. The exercise is set-theoretical, defining all notions and indicating assumptions and philosophical points of disagreement, while being easy to translate to other formal expressions . The issue of a logic for A-theories of time is treated towards the end, where I sketch ‘copresent’ operators for capturing the idea of temporal passage. The main conclusion will be that, while circularity (...) threatens both families of theories, the growing block theory (belonging to the A-theory) is the least objectionable philosophically. (shrink)

This article presents a quantitative way of modeling the interim decisions of clinical trials. While statistical approaches tend to focus on the epistemic aspects of statistical monitoring rules, often overlooking ethical considerations, ethical approaches tend to neglect key epistemic dimension. The proposal is a second-order decision theoretic framework. The framework provides means for retrospective assessment of interim decisions based on a clear and consistent set of criteria that combines both ethical and epistemic considerations. The framework is broadly Bayesian and addresses (...) a fundamental question behind many concerns about clinical trials: What does it take for an interim decision (e.g., whether to stop the trial, or continue) to be a good decision? I provide simulation illustrating the modeling of interim decisions counterfactually using the framework. (shrink)

Gdy kartkuje się tę książkę, to od razu rzuca się w oczy mieszanie treści biblijnych z szeregiem pojęć matematycznej i fizycznej natury. Gdy zaś próbuje się ją podczytywać, wtedy z kolei natrafia się na język filozoficzny. Mamy łączenie radykalnie odmiennych porządków sensu. Z jednej strony staje filozoficzna interpretacja pierwszych dziesięciu zdań Biblii, z drugiej szczególny opis kilku obiektów matematycznych i fizycznych. Pierwszym wrażeniem jest doznanie nieprzystawalności. Co jedno może mieć wspólnego z drugim? Oryginalność zestawienia jest uzasadniona celem prezentowanych rozważań. Najogólniej, (...) chodzi tu o możliwie odpowiedzialną, metodycznie kontrolowaną, racjonalną próbę interpretacji początku Biblii za pomocą pojęć filozoficznych, a następnie o odświeżenie wybranych symboli z początku Genesis za pomocą zmetaforyzowanych pojęć matematycznych i fizycznych. (shrink)

Clinical ethicists tend to see themselves as moral experts to be called in when clinicians encounter a particularly difficult moral problem. Drawing on a naturalized moral epistemology, we argue that clinicians already have the moral knowledge they need—the norms and values that guide clinical practice are built right into the various health care professions. To reflect on their practice, clinicians need to (a) be aware of their own professional norms and values; (b) be able to express them to their colleagues, (...) their patients, and the patients' families; and (c) work together with these other actors to provide ethically responsible care. The ethicist's job is to use her own training in three kinds of philosophical reflection as the basis for teaching clinicians how to think about what they do. (shrink)

Despite efforts from regulatory agencies (e.g. NIH, FDA), recent systematic reviews of randomised controlled trials (RCTs) show that top medical journals continue to publish trials without requiring authors to report details for readers to evaluate early stopping decisions carefully. This article presents a systematic way of modelling and simulating interim monitoring decisions of RCTs. By taking an approach that is both general and rigorous, the proposed framework models and evaluates early stopping decisions of RCTs based on a clear and consistent (...) set of criteria. The framework allows decision analysts to generate and quickly answer ‘what-if’ questions by simulating alternate trial scenarios. I illustrate the framework with a case study of an RCT that was stopped early due to harm. This was a trial of vitamin A supplement in relation to HIV transmission from mother-to-child through breastfeeding. (shrink)

Referring to the session "Science and religion" (Filozofia Nauki 1/2006) - esp. to Jan Wolenski's contribution article "Return to the theory of double truth" - the author presents two ways of interpreting the meaning of religion statements. According to one of them, the statements may be shown to possess some kind of empirical content, due to their definitional connection with empirical terms of everyday language, and, in consequence, may bear logical relations to empirical statements. According to the other way of (...) interpreting religion statements, they appear to be devoid of any empirical content and - s Wolenski claims - cannot be supported or threatened by any empirical data. (shrink)

The chief aim of the article is to give an analysis of Russellś semantical theory of ordinary proper names with respect to the problem of reference. The problem can be stated in the following way: proper names are employed as devices for identifying objects - how is it possible that they can serve for this purpose? It is argued that Russellś semantics is unable to solve the problem and, moreover, it is impossible to state the problem within its conceptual framework. (...) Russellś identification of the referent of a name with nameś meaning, together with his logico-semantical distinction between complete and incomplete symbols, and his epistemology of sense-data implies that grammatically proper names are, in fact, disguised descriptions. It is argued that in order for the theory to work it must rely on an infallible or ideal speaker. (shrink)

Although the managerial practice of cheating spans complex and heterogeneous situations, most business ethics scholars consider that the very idea of cheating is indefensible on moral grounds, and quickly dismiss it as wrongdoing. This paper proposes to fine-tune this conventional moral assessment by arguing that some forms of cheating can be justified—or at least excused. To do so, it starts with a value-free definition of cheating that covers a wide diversity of situations: “breaking the rules while deliberately leading or allowing (...) others to think they have been respected.” While using this definition at the metaethical level, the paper contends that the moral assessment of cheating depends on the obligation to comply with the rules. There are rules which do not entail moral obligations, and there are special circumstances where other more important obligations override the obligation to comply with the rules. Furthermore, the paper argues that respecting the penalty rules also influences the moral assessment of cheating on the rules. The key interest of this endeavor lies in contributing to building a more solid theoretical framework for the study of cheating in management, which may replace our common prejudices and basic intuitions on this matter. (shrink)

The adoption of personalisation as the principle on which policy and practices for social care in England should be developed has been hailed as marking a fundamental transformation in the nature of social care and the experiences of service users. This article examines both the discourse of personalisation and the practices that are being adopted to implement this from an ethic of care perspective. It adopts an approach based on Sevenhuijsen's ‘Trace’ analysis to trace the normative frameworks in key policy (...) documents (in particular Putting People First), noting that critics of care have largely succeeded in relegating care to a marginal position within policy discourse and that a relational sensibility is largely absent within this. The article considers the practices associated with personalisation in relation to the moral principles of an ethic of care and conceptions of the ‘individual’ within these. It addresses the implications of this approach for broader political and policy issues: the universality of provision, collective responsibility for welfare and well-being, and broader issues of social justice in conditions of vulnerability. (shrink)

In the Netherlands there is a growing debate over the possibility of introducting ‘compassionate interference’ as a form of good psychiatric care. Instead of respecting the autonomy of the patient by adopting an attitude of non‐interference, professional carers should take a more active and commited role. There was a great deal of hostile reaction to this suggestion, the most commonly voiced criticism being that it smacked of ‘modern paternalism’. Still, the current conception of care leaves us with a paradox. On (...) the one hand patients are regarded as individuals who have a strong interest in ( and a right to) freedom and non‐interference; on the other hand many of them have a desperate need for flourishing, viable relationships. In fact, part of their problem is that they cannot relate very well with other people. This creates a dichotomy, because respecting patients' autonomy often means that they cannot be given the help they so desperately need. In this respect current care practices do not answer the caring needs of these patients.The criticism on care practices is to be considerd as important. It invites us to reexamine and reevaluate the current conception of caring relationships and its main values. In line with this reexamination an alternative perspective on care is introduced in this paper, a perspective in which `compassionate interference' is not so much a threat to autonomy, but a means of attaining autonomy. For this we need a different definition of autonomy than that commonly used in current care practice. (shrink)

In this article, the author examines Romanian child protection reforms during European Union accession as a case of externally facilitated modernization aimed at solving acute social problems. The data for this case study came primarily from fifty-three unstructured interviews with civil servants, civil society representatives, and EU officials. The author finds that in a similar manner to other externally driven modernization projects, the belief according to which Western institutions constituted a universal blueprint, applicable regardless of particular contexts and historical legacies, (...) led to unintended consequences. What is more, because the reformers did not envisage that Western institutions might carry their own pathologies, they ended up replicating some of these pathologies. The study suggests that the goal of externally facilitated public policy should not be to create replicas of Western institutions but to spur local innovation that takes advantage of successful Western institutional logics. (shrink)